Molecular Biology: Silencing Unlimited

Molecular Biology: Silencing Unlimited

Heterochromatin domains are essential for normal chromosome functions. The Eri1 ribonuclease is a negative regulator of the RNA interference machinery; recent studies have shown that, in fission yeast lacking Eri1, heterochromatin formation is more promiscuous.

Editorial: Secondary Metabolism. An Unlimited Foundation for Synthetic Biology

The foundations of synthetic biology rely on the concept that all living systems are constituted by functional and structural modules that could be rationally engineered to build organisms that are not easily generated by evolution. However, the cellular complexity and metabolic diversity found in organisms present both a significant challenge and opportunity to foster this interdisciplinary sc...

Systems biology versus molecular biology

Systems biology and molecular biology can answer the same question in quite different ways, and frequently the answers given by one sub-discipline seem no answer at all to the other. For many molecular biologists, a systemslevel explanation leaves them feeling that, until the underlying molecular mechanisms are known, the approach is hopelessly superficial. For systems biologists, on the other ...

Switching from prokaryotic molecular biology to eukaryotic molecular biology.

In the history of biology, the early 1950s to the mid-1960s represent a period of landmark discoveries that led to the establishment of a new science named Molecular Biology. The discovery of the double helical structure of DNA byWatson and Crick in 1953 facilitated the formulation of specific questions related to the hottest questions of the time, gene replication and expression. Many ambitiou...

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